Formaldehyde → HCID 70073535, compound

Participants

Reaction Steps

1.13 g of 2-(4-chloroindol-3-ylmethyl)-2-aminomalonic acid diethylester hydrochloric and 80 mg of paraformaldehyde are boiled at reflux for about 15 minutes in 30 ml of benzene until the Ninhydrin reaction has disappeared. After cooling, the crystalline precipitate is suction-filtered and recrystallized from benzene. 1.05 g of 5-chloro-1,2,3,4-tetrahydro-β-carbolin-3,3-dicarboxylic acid ethyl ester hydrochloride of melting point 157° C. is obtained.

Provenance & Evidence