Sulfur → HCID 10244226, compound

Participants

Reaction Steps

720 mg of 6-fluoro-1,2,3,4-tetrahydro-β-carbolin-3-carboxylic acid ethyl ester and 130 mg of dry sulphur are heated to boiling under nitrogen in 5 ml of xylene. After cessation of dehydrogenation (about 20 hours, thin-layer chromatography check), the solution is concentrated by evaporation in vacuo, and the residue chromatographed on silica gel with chloroform ethanol (95:5). 300 mg of 6-fluoro-β-carbolin-3-carboxylic acid ethyl ester of melting point 284° C. (decomposition) is obtained. After reaction with hydrochloric acid, the hydrochloride which melts at 295° C., with decomposition, is obtained.

Provenance & Evidence