Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | ethyl 6-bromo-9H-pyrido[3,4-b]indole-3-carboxylate | HCID 13037312 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | HCID 13037353 | HCID 13037353 | — |
Reaction Steps
4 ml of dimethylformamide, 250 mg of copper (I) iodide and 160 mg of 6-bromo-β-carbolin-3-carboxylic acid ethyl ester are added to a solution, prepared under argon, of 230 mg of sodium in 3 ml of absolute methanol, and the whole is heated for 6 hours at 145° C. The solution is then concentrated in vacuo, the residue is washed with water, dried and chromatographed on silica gel with chloroform-methanol (8:2). 67 mg of 6-methoxy-β-carbolin-3-carboxylic acid dimethylamide of melting point 195° C. (decomposition) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05010077 |
|---|
| Source dataset | uspto-grants-1991_04 |
|---|
| ORD ID | ord-aadcc3b8a5e8433c8edfeee83ecc9d33 |
|---|
| Source note | uspto-grants-1991_04 |
|---|
