反应详情

12 g of β-carbolin-3-carboxylic acid methyl ester is suspended in 130 ml of methanol; 130 ml of 40% aqueous methylamine is added thereto and the whole is boiled at reflux for 2 hours. After cooling, the mixture is suction-filtered. By extraction with 300 ml of hot methanol and crystallization from dimethylformamide/hexane, the β-carbolin-3-carboxylic acid N-methylamide of melting point 264°-266° C. is isolated from the filter residue in 43% yield.

1. temperatureat reflux for 2 hours
2. temperatureAfter cooling
3. filtrationthe mixture is suction-filtered
4. extractionBy extraction
5. customwith 300 ml of hot methanol and crystallization from dimethylformamide/hexane