Ethanol → HCID 86744734, compound

HRID 1085464Notes

Reaction equation

HRID 1085464 reaction equation
[NH:1]([C:3]1[N:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH:10]2[CH2:12][CH2:11]2)[N:4]=1)[NH2:2].C[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O.[CH2:23](O)C>>[CH3:9][C:7]1[CH:6]=[C:5]([CH:10]2[CH2:11][CH2:12]2)[N:4]=[C:3]([NH:1][N:2]=[C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])[CH3:14])[N:8]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 71481-Phenyl-1-propanoneHCID 20060099HCID 20060099, compound

Product 1

HCID 86744734HCID 86744734, compound

Procedure

3.3 g of 2-hydrazino-4-methyl-6-cyclopropylpyrimidine and 2.7 g of 2-methylacetophenone are heated to boiling in 40 ml of ethanol and boiled under reflux for 20 hours with stirring. The reaction solution is then cooled and the solvent is evaporated off in vacuo. For purification, the oily residue is chromatographed using hexane/ethyl acetate (2:1) over a column of silica gel.

Workup

  1. temperatureunder reflux for 20 hours
  2. temperatureThe reaction solution is then cooled
  3. customthe solvent is evaporated off in vacuo
  4. customFor purification
  5. customthe oily residue is chromatographed

Sources & evidence

ORD record
ord-47e23cb0af584577b7e81ede76200279
Source dataset
uspto-grants-1991_04
Patent number
US05010082

Reaction notes

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