Ammonium Chloride → HCID 20060174, compound

Participants

Reaction Steps

The reaction mixture was kept under reflux for 1 h after the exotherm had subsided and cooled to ambient temperature. To the reaction mixture was added 27.85 g of 4-chloro-1-(2-thienyl)-butan-1-on in 75 ml of anhydrous tetrahydrofuran. The reaction mixture was heated at reflux for 0.5 h, cooled and 175 ml of saturated ammonium chloride solution was introduced, and the mixture was extracted with 3×200 ml of ethyl acetate. The combined extracts were dried (MgSO4) and evaporated to an oil. Flash chromatography on silica gel (Art. 9385) eluting with heptane/ethyl acetate (40:1) provided 2-(3-methylthien-2-yl)-2-(thien-2-yl)tetrahydrofuran (25.58 g, 69%) as an oil.

Provenance & Evidence