反应详情

温度

50 °C

A solution of ethyl bromopyruvate (2.14 g) in ethanol (5 ml) was added to a suspension of 3-nitrobenzenecarbothioamide (2.00 g) in ethanol (15 ml) at room temperature. The reaction mixture was stirred at 50° C. for 2 hours and ten minutes. The solvent was removed by evaporation under reduced pressure. To the residue was added a saturated aqueous solution of sodium bicarbonate (50 ml) and ethyl acetate (100 ml). The precipitates were collected by filtration and recrystallized from a mixture of chloroform and n-hexane to give ethyl 2-(3-nitrophenyl)-4-thiazolecarboxylate (1.59 g).

1. customThe solvent was removed by evaporation under reduced pressure
2. additionTo the residue was added a saturated aqueous solution of sodium bicarbonate (50 ml) and ethyl acetate (100 ml)
3. filtrationThe precipitates were collected by filtration
4. customrecrystallized from a mixture of chloroform and n-hexane