Acetic Anhydride → HCID 10036926, compound

HRID 1085511Notes

Reaction equation

HRID 1085511 reaction equation
[CH:1]1([N:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH2:6][NH2:7])[CH2:3][CH2:2]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([NH:7][CH2:6][CH2:5][N:4]([CH:1]1[CH2:2][CH2:3]1)[CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 332216N'-benzyl-N'-cyclopropylethane-1,2-diamine

Product 1

HCID 10036926HCID 10036926, compound

Procedure

19 g (0.1 mole) of N-cyclopropyl-N-benzylethylenediamine are added at 50° C. to 15.3 g (0.15 mole) of acetic anhydride. When the exothermic phase is over, the mixture is kept for further 30 minutes at 70° C., then cooled down and poured into ice. The organic phase is extracted with toluene and, after drying and evaporation, it gives a residue of gas-chromatographically pure N-acetyl-N'-cyclopropyl-N'-benzylethylenediamine with an almost quantitative yield.

Workup

  1. temperaturecooled down
  2. additionpoured into ice
  3. extractionThe organic phase is extracted with toluene
  4. customafter drying
  5. customevaporation, it

Sources & evidence

ORD record
ord-d6229c917fbf4cbaa3a7254f207c0255
Source dataset
uspto-grants-1991_04
Patent number
US05010108

Reaction notes

Loading…