HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1085629Generated: October 26, 2026
Ethanol → 1-(4-Allyloxy-5-iodo-3-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione
https://huagongshe.com/reaction/1085629
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Benzaldehyde, 3-iodo-5-methoxy-4-(2-propenyloxy)- | HCID 4382547 | — |
| Reactant | 2-Propen-1-one, 1-(3,4,5-trimethoxyphenyl)- | HCID 10443524 | — |
| Catalyst | Thiazole | HCID 9256 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(4-Allyloxy-5-iodo-3-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione | HCID 15718026 | — |
Reaction Steps
A mixture of 4-allyloxy-5-iodo-3-methoxybenzaldehyde (46 g, 0.15 mol), 3,4,5-trimethoxyphenyl vinyl ketone (38 g, 0.16 mol) and thiazole catalyst (6 g, 0.07 mol) in triethylamine (200 ml) was heated, with stirring, at 70° C. for 2 hours, and kept at room temperature overnight. Ethanol was added to the solid mass, filtered, and the filtrate was evaporated to a residue, which was purified by HPLC (hexane-ethyl acetate; 2:1, v/v) to afford 1-(4-allyloxy-5-iodo-3-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione, m.p. 113°-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05010100 |
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| Source dataset | uspto-grants-1991_04 |
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| ORD ID | ord-fcca7019432445eaa6b9a4ac8bcbbd5a |
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| Source note | uspto-grants-1991_04 |
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