Water → HCID 15003621, compound

HRID 1085645Notes

Reaction equation

HRID 1085645 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[C:4]([Cl:10])[N:3]=1.[CH3:11][O-:12].[Na+].N1C=CC=NC=1.O>CO>[Cl:10][C:4]1[C:5]([Cl:9])=[C:6]([O:12][CH3:11])[N:7]=[C:2]([CH3:1])[N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 9260PyrimidineHCID 2310544,5,6-Trichloro-2-methylpyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 15003621HCID 15003621, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution containing 38 g (0.17 mol) of 2-methyl-4,5,6-trichloropyrimidine in 200 ml of methanol was cooled in an ice bath to 10° C.-15° C. and sodium methoxide as a 25 percent solution in methanol was added slowly with stirring until the starting pyrimidine could no longer be detected by GLC analysis. Water was then added and the resulting mixture was extracted with methylene chloride. Removal of the solvent and other volatiles from the extract by evaporation under reduced pressure left the title compound as a white powder melting at 77° C.-78° C.

Workup

  1. temperaturewas cooled in an ice bath to 10° C.-15° C.
  2. extractionthe resulting mixture was extracted with methylene chloride
  3. customRemoval of the solvent and other volatiles from the
  4. extractionextract by evaporation under reduced pressure
  5. waitleft the title compound as a white powder melting at 77° C.-78° C.

Sources & evidence

ORD record
ord-3894e988d74c4d0e92568bce1d0121ef
Source dataset
uspto-grants-1991_04
Patent number
US05010195

Reaction notes

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