HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → Ethyl 4-[[(methylphenylamino)thioxomethyl]amino]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | Ethyl 4-isothiocyanatopiperidine-1-carboxylate | HCID 3018454 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 4-[[(methylphenylamino)thioxomethyl]amino]-1-piperidinecarboxylate | HCID 14576021 | 42% |
Reaction Steps
A mixture of 107 parts of ethyl 4-isothiocyanato-1-piperidinecarboxylate, 53.5 parts of N-methylbenzenamine, 1 part of N,N-dimethyl-4-pyridinamine and 450 parts of methylbenzene was stirred and refluxed overnight. After cooling, the reaction mixture was evaporated. The residue was crystallized from 2,2'-oxybispropane. The product was filtered off and dried, yielding 68 parts (42%) of ethyl 4-[[(methylphenylamino)thioxomethyl]amino]-1-piperidinecarboxylate; mp. 95.2° C. (14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05010198 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-e78cfa6147cb4af5bf90bd6d90f738bb |
| Source note | uspto-grants-1991_04 |