HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 3-Fluorophenyl isothiocyanate | HCID 9834 | — |
| Reactant | 1-Piperidinecarboxylic acid, 4-(methylamino)-, ethyl ester | HCID 11063140 | — |
| Product | Ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate | HCID 15725103 | 90% |
Reaction Steps
To a stirred solution of 91 parts of ethyl 4-(methylamino)-1-piperidinecarboxylate in 420 parts of 2,2'-oxybispropane were added dropwise 75 parts of 1-fluoro-3-isothiocyanatobenzene. Upon completion, stirring was continued for 1 hour. The precipitated product was filtered off and dried, yielding 150 parts (90%) of ethyl 4-[[(3-fluorophenyl)aminothioxomethyl]methylamino]-1-piperidinecarboxylate; mp. 175.2° C. (17).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05010198 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-2e44dc3bde004248a99ddb1dba41eed4 |
| Source note | uspto-grants-1991_04 |