Sodium Hydroxide → HCID 11961759, compound

HRID 1085677Notes

Reaction equation

HRID 1085677 reaction equation
O.Br.Br.[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[OH-].[Na+]>O>[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20060646HCID 20060646, compound

Product 1

HCID 11961759HCID 11961759, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 427 parts of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine dihydrobromide monohydrate in 1500 parts of water was treated with a sodium hydroxide solution 50%. The product was extracted twice with trichloromethane. The combined organic layers were washed with water, dried, filtered and evaporated. The residue was crystallized from 490 parts of 2,2'-oxybispropane. The product was filtered off and dried, yielding 248 parts (100%) of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine; mp. 86.9° C. (68).

Workup

  1. extractionThe product was extracted twice with trichloromethane
  2. washThe combined organic layers were washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized from 490 parts of 2,2'-oxybispropane
  7. filtrationThe product was filtered off
  8. customdried

Sources & evidence

ORD record
ord-b9b54207ea314856b9fc54e5d4ed7c64
Source dataset
uspto-grants-1991_04
Patent number
US05010198

Reaction notes

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