反应详情

A mixture of 1.65 parts of 1-(4-fluorobenzoyl)aziridine (solution in benzene 1.2M), 2.1 parts of N-(4-piperidinyl)-2-benzoxazolamine and 90 parts of methylbenzene was stirred and refluxed overnight. The reaction mixture was evaporated and the residue was crystallized from 2-propanol. The product was filtered off and recrystallized from 2-propanone, yielding 1.3 parts (34%) of N-[2-[4-[(2-benzoxazolyl)-amino]-1-piperidinyl]ethyl]-4-fluorobenzamide; mp. 173.3° C. (448).

1. temperaturerefluxed overnight
2. customThe reaction mixture was evaporated
3. customthe residue was crystallized from 2-propanol
4. filtrationThe product was filtered off
5. customrecrystallized from 2-propanone