Benzocaine → HCID 15734510, compound

HRID 1085764Notes

Reaction equation

P(Cl)(Cl)(Cl)(Cl)Cl.[NH2:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=1.[CH:19]([Cl:22])(Cl)Cl>>[CH2:15]([O:14][C:12]([C:11]1[CH:10]=[CH:9][C:8]([NH:7][C:12](=[N:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=2)[C:11]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:9][CH:10]=2)=[CH:18][CH:17]=1)=[O:13])[CH3:16]

Participants

Reactant 3

HCID 2337Benzocaine

HCID 6212Chloroform

HCID 24819Phosphorus pentachloride

Product 1

HCID 15734510HCID 15734510, compound

Procedure

N,N'-Bis(4-ethoxycarbonylphenyl)-4-chlorobenzamidine (12) was prepared from ethyl 4-[N-(4-chlorobenzoyl)] aminobenzoate, phosphorus pentachloride, and ethyl 4-aminobenzoate; white crystals: mp 171.0°-172.5° C. 1H-NMR (CDCl3) 8.0-6.9 (m, 13H), 4.2 (q, 4H, J=7 Hz), 1.5 (t, 6H, J=7 Hz); IR (CHCl3) 3420, 3330, 1705, 1590; MS (m/e) 450, 452 (M+), 286 (base).

Sources & evidence

ORD record: ord-bf77e7b65d0f4a5abecd942fcf3c523e
Source dataset: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05011628

Reaction notes

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