Dimethylamine → HCID 20058923, compound

Participants

Reaction Steps

5.5 g (0.037 mol) of sodium iodide are added to 13 g (0.037 mol) of 6-methyl-6,11-dihydro-11-(3-chloropropionyl)-dibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide in 100 ml of acetone, and the mixture is heated under reflux for 30 minutes. After cooling, 7 ml of aqueous 33% dimethylamine are added, and the mixture is kept with stirring at ambient temperature for 16 hours. It is concentrated and the residue is treated with 5% HCl, the insoluble fraction is filtered off and the filtrate is alkalized with NaHCO3 ; a solid forms, which is filtered off, washed with water and dried.

Provenance & Evidence