Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 14868661 | HCID 14868661 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 14868673 | HCID 14868673 | — |
Reaction Steps
0.9 g (0.027 mol) of 80% sodium hydride are added to 7 g (0.027 mol) of 6-methyl-6,11-dihydro-dibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide in 200 ml of dioxane, and the mixture is heated for 30 minutes at 80° C. After cooling, 5.4 g of trichloromethyl chloroformate are added dropwise, with cooling in an ice bath, and the mixture is left to stand overnight. Gaseous NH3 is then introduced up to saturation, the mixture is filtered, and the filtrate is concentrated and diluted with water. This gives a solid which is filtered, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05011833 |
|---|
| Source dataset | uspto-grants-1991_04 |
|---|
| ORD ID | ord-27dbf9b7e3f945b389b933d0d584c856 |
|---|
| Source note | uspto-grants-1991_04 |
|---|
