反应详情

A mixture comprising 330 mg of 4,5-dichloro-3(2H)pyridazinone, 1.12 g of 4-methoxy-1-naphthylmethylamine and 30 ml of ethanol, was refluxed under stirring overnight. The solvent was evaporated under reduced pressure, and a mixture of ethyl acetate and ethyl ether was poured to the residue, whereupon precipitated crystals were collected by filtration. The product was recrystallized from a mixture of methanol/water to obtain 410 mg of the above identified command as slightly yellow crystals having a melting point of from 265° to 266° C.

1. temperaturewas refluxed
2. customThe solvent was evaporated under reduced pressure
3. additiona mixture of ethyl acetate and ethyl ether
4. additionwas poured to the residue
5. customwhereupon precipitated crystals
6. filtrationwere collected by filtration
7. customThe product was recrystallized from a mixture of methanol/water
8. customto obtain 410 mg of the
9. customof from 265° to 266° C.