Iodoethane → HCID 15007190, compound

Participants

Reaction Steps

A mixture comprising 100 mg of 4-chloro-5-(4-methoxy-1-naphthylmethylamino)-6-nitro-3(2H)pyridazinone (Compound No. 30) prepared in Preparation Example 4, 218 mg of ethyl iodide, 193 mg of potassium carbonate and 30 ml of methyl ethyl ketone, was refluxed under stirring for 1.5 hours. The reaction mixture was filtered, and the solvent of the filtrate was distilled off under reduced pressure. Water was poured to the residue thus obtained, and the mixture was extracted with benzene. The extract was washed with water and with a saturated sodium chloride aqueous solution and dried over sodium sulfate. Then, the solvent was distilled off to obtain 110 mg of the above identified compound as a slightly yellow brown caramel substance.

Provenance & Evidence