反应详情

A mixture comprising 350 mg of 4,5 dichloro 6-1-propoxy-3(2H)pyridazinone, 1.23 g of 4-methoxy-1-naphthylmethylamine and 30 ml of a mixture of water/1,4-dioxane (volume ratio of 1/1), was refluxed under stirring for 3.5 hours. The reaction mixture was concentrated, and precipitated crystals were collected by filtration and recrystallized from a mixture of methanol/water to obtain 420 mg of the above identified compound as colorless crystals having a melting point of from 244° to 247° C.

1. temperaturewas refluxed
2. concentrationThe reaction mixture was concentrated
3. customprecipitated crystals
4. filtrationwere collected by filtration
5. customrecrystallized from a mixture of methanol/water
6. customto obtain 420 mg of the
7. customof from 244° to 247° C.