化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 5-phenyl-1,3-thiazole-4-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 5-phenylthiazole-4-carboxylate | HCID 12300673 | — |
| 生成物 | 5-phenyl-1,3-thiazole-4-carboxylic Acid | HCID 944813 | 72% |
反応手順
The ethyl 5-phenylthiazole-4-carboxylate was hydrolyzed according to known methods with 2N aqueous sodium hydroxide solution at 70° for 30 minutes, whereby, after acidification, there was obtained in 72% yield 5-phenyl-4-thiazolecarboxylic acid which melted at 189°-190° after recrystallization from methanol/diethyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05011849 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-1117adfa47b24e9487183e996d0fdc8a |
| 出典メモ | uspto-grants-1991_04 |