Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → Ethyl alpha-dimethylaminocinnamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Glycine, N,N-dimethyl-, ethyl ester | HCID 118412 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ethyl alpha-dimethylaminocinnamate | HCID 708380 | 60% |
반응 단계
Benzaldehyde, N,N-dimethylglycine ethyl ester and sodium hydride were reacted in ether with the addition of a catalytic amount of ethanol according to the method described in Lieb. Ann. Chem. 703 (1967) 37°-43 to give ethyl α-dimethylaminocinnamate. This compound was then reacted according to the method described in Tetrahedron Letters, 46, (1978) 4573°-4574 with oxalyl chloride and hydrazine in 60% yield to give ethyl 4-phenyl-3-pyrazolecarboxylate, melting point 164°-165° after recrystallization from ethanol/diethyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05011849 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-42ce2aa473b54529ba07510feaec3441 |
| 출처 메모 | uspto-grants-1991_04 |