N-BOC-ethylenediamine → HCID 178453699, compound

HRID 1085843Notes

Reaction equation

HRID 1085843 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([C:13]([O:15]CC)=O)=[N:10][NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25]>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:9]([C:13]([NH:18][CH2:19][CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:26])([CH3:25])[CH3:27])=[O:15])=[N:10][NH:11][CH:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 178470486HCID 178470486, compound

Product 1

HCID 178453699HCID 178453699, compoundYield 64.6%

Procedure

4.6 q (19.64 mmol) of ethyl 4-(3-fluorophenyl)-3-pyrazolecarboxylate were reacted with t-butyl (2-aminoethyl)carbamate in an analoqous manner to that described in Example 16. Chromatoqraphy of the crude product and recrystallization from ethyl acetate/hexane yielded 4.4 g (64.6%) of t-butyl [2-(4-(3-fluorophenyl)-3-pyrazolecarboxamido)ethyl]carbamate as white crystals, melting point 175°-176°.

Workup

  1. customChromatoqraphy of the crude product and recrystallization from ethyl acetate/hexane

Sources & evidence

ORD record
ord-56f0244b2a884ace85ab62f18d010f80
Source dataset
uspto-grants-1991_04
Patent number
US05011849

Reaction notes

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