HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → HCID 19768570, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl isocyanoacetate | HCID 533707 | — |
| Reactant | HCID 19768519 | HCID 19768519 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 19768570 | HCID 19768570 | 75.4% |
Reaction Steps
Analogously to the method described in Synthesis 10, (1976), 681-682, 47 g (169 mmol) of O-methyl 3-iodothiobenzoate were reacted with ethyl isocyanoacetate in the presence of 1-5% powdered potassium hydroxide in ethanol. Recrystallization from ether yielded 45.8 g (75.4%) of ethyl 5-(3-iodophenyl)-4-thiazolecarboxylate as ochre crystals, melting point 77°-78°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05011849 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-2de5c50a96bb4f83a87fa502e62d212a |
| Source note | uspto-grants-1991_04 |