N-BOC-ethylenediamine → HCID 54091391, compound

HRID 1085851Notes

Reaction equation

HRID 1085851 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([C:8]2[S:12][CH:11]=[N:10][C:9]=2[C:13]([OH:15])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23]>>[I:1][C:2]1[CH:3]=[C:4]([C:8]2[S:12][CH:11]=[N:10][C:9]=2[C:13]([NH:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:15])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 19768756HCID 19768756, compound

Product 1

HCID 54091391HCID 54091391, compoundYield 88.1%

Procedure

Reaction of 5.0 g (15.1 mmol) of 5-(3-iodophenyl)-4-thiazolecarboxylic acid with 2.6 g (16.2 mmol) of t-butyl (2-aminoethyl)carbamate in an analogous manner to that described in Example 1(E) yielded 6.3 g (88.1%) of t-butyl [2-[5-(3-iodophenyl)-4-thiazolecarboxamido]ethyl]carbamate as white crystals, melting point 111°-112°.

Sources & evidence

ORD record
ord-f7277b8d55c64800a4eb9bb11a140f26
Source dataset
uspto-grants-1991_04
Patent number
US05011849

Reaction notes

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