Acetic Acid → HCID 19911575, 화합물

HRID 1085858노트

반응식

HRID 1085858 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][NH:8]N1C=CC=CC1N.Cl.[Cl:17][CH2:18][C:19](=[NH:23])OCC.[C:24](O)(=O)[CH3:25]>>[Cl:17][CH2:18][C:19]1[N:8]([CH2:7][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[C:2]2=[N:1][CH:6]=[CH:24][CH:25]=[C:3]2[N:23]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 12470659Ethyl 2-chloroethanecarboximidate hydrochlorideHCID 67896527HCID 67896527, 화합물

생성물 1

HCID 19911575HCID 19911575, 화합물수율 100%

실험 절차

To a stirred solution of 3.6 parts of N-(2-pyrazinylmethyl)-1,2-pyridinediamine in 30 parts of acetic acid were added 4.24 parts of ethyl 2-chloroethanimidate monohydrochloride. The reaction mixture was stirred first for 21 hours at room temperature and then for a few minutes at 90° C. The whole was evaporated and the residue was taken up in water. The aqueous layer was treated with sodium carbonate and the product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 3.9 parts (100%) of 2-(chloromethyl)-3-(2-pyrazinylmethyl)-3H-imidazo[4,5-b]-pyridine as a residue (int. 29).

후처리

  1. waitfor a few minutes at 90° C
  2. customThe whole was evaporated
  3. additionThe aqueous layer was treated with sodium carbonate
  4. extractionthe product was extracted with dichloromethane
  5. customThe extract was dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-97bfee01890147788adc0ba4ded56158
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011842

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