Water → 2-Amino-6-(4-chlorophenoxy)-4-fluoropyrimidine

Participants

Reaction Conditions

Reaction Steps

2.52 g (0.038 mol) of 85% sodium hydroxide were dissolved in 50 ml of methanol, 4.9 g (0.0382 mol) of 4-chlorophenol were added, and the mixture was evaporated to dryness. The residue of salt obtained in this way was taken up in 50 ml of N-methyl-2-pyrrolidone and, at 25° C., 5.0 g (0.0382 mol) of 2-amino-4,6-difluoropyrimidine were added, and the mixture was stirred at 140° C. for 4 hours. After the reaction mixture had been cooled to 25° C. it was stirred into 500 ml of water, and the resulting precipitate was isolated. 7.4 g (81% of theory) of the title compound of melting point 223°-226° C. were obtained in this way.

Provenance & Evidence