5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan

HRID 1085909Notes

Reaction equation

HRID 1085909 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>COCCO>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 867447425'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide

Product 1

HCID 131270Flosequinoxan

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (0.20 g), prepared in a similar manner to that described in Example 11, in 2-methoxyethanol (25 ml) was heated to reflux. Heating under reflux at 127° was continued for 2 hours. The mixture was allowed to cool to ambient temperature and then evaporated in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 233.5°-235° (0.19 g).

Workup

  1. temperaturewas heated to reflux
  2. temperatureHeating
  3. temperatureunder reflux at 127°
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-7b4ebf1c7575408597c6bb15fa7f5419
Source dataset
uspto-grants-1991_04
Patent number
US05011931

Reaction notes

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