5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan

HRID 1085911Notes

Reaction equation

HRID 1085911 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>[OH-].[Na+]>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 867447425'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide

Product 1

HCID 131270Flosequinoxan

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (1.50 g), prepared in a similar manner to that described in Example 11, and aqueous sodium hydroxide solution (1M; 40 ml) was stirred for 2 hours. The mixture was filtered, the solid washed with water (2×10 ml) and then dried in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234°-235° (1.19 g).

Workup

  1. customprepared in a similar manner to that
  2. filtrationThe mixture was filtered
  3. washthe solid washed with water (2×10 ml)
  4. customdried in vacuo

Sources & evidence

ORD record
ord-f673797ccbd14ce09739de13439c9bff
Source dataset
uspto-grants-1991_04
Patent number
US05011931

Reaction notes

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