Imidazole → HCID 131716834, compound

Participants

Reaction Steps

A solution of 6 g of the diol 5, 6.5 ml of t-butyldiphenylchlorosilane and 3.4 g of imidazole in 120 ml of dimethylformamide (DMF) was stirred at 0° C. for 2 hours. The mixture was then concentrated under vacuum and the residue was dissolved in 300 ml of 5 hexanes: 1 EtOAc. The solution was washed with 150 ml of water and then 150 ml of saturated aqueous sodium chloride solution (brine). The organic phase was dried over sodium sulfate and concentrated under vacuum to provide the title compound.

Provenance & Evidence