2,6-Lutidine → HCID 131716836, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 140 mg of the primary tosylate 26, 0.10 ml of 2,6-lutidine and 0.10 ml of t-butyldimethylsilyl triflate in 8 ml of methylene chloride was stirred at 0° C. for 1 hour. A few drops of water were added and the mixture concentrated under vacuum. The residue was diluted with diethyl ether and the solution filtered thru silica gel. The filtrate was concentrated under vacuum and chromatography of the residue over silica gel (6 hexanes: 1 EtOAc) provided the title compound.

Provenance & Evidence