Quinone → HCID 20059337, compound

Participants

Reaction Steps

23.47 g (0.1011 mol) of 4,5-bis-trifluoromethyl-2-oxo-2H-pyran, 54.62 g (0.5053 mol) of 1,4-benzoquinone and 26.30 g (0.3026 mol) of MnO2 in 225 ml of 1,2-dichlorobenzene are heated at 180° C. for 12 hours. The reaction mixture is then diluted with 200 ml of CHCl3 and filtered through Hyflo®. After the chloroform has been removed by distillation, the distillation residue is chromatographed over a column packed with 1300 g of SiO2 (mobile phase: first cyclohexane and then CHCl3 ; 0.3 bar excess pressure). Yield 17.94 g (60.3%), melting point: 91°-94° C.

Provenance & Evidence