tert-Butyl carbazate → HCID 54257061, compound

HRID 1085950Notes

Reaction equation

HRID 1085950 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)(=O)[CH2:2][CH3:3].[C:11]([O:15][C:16](=[O:19])[NH:17][NH2:18])([CH3:14])([CH3:13])[CH3:12]>C(O)C>[N:8]1[CH:9]=[CH:10][C:5]([C:1](=[N:18][NH:17][C:16]([O:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:19])[CH2:2][CH3:3])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 743431-(4-Pyridinyl)-1-propanone

Product 1

HCID 54257061HCID 54257061, compoundYield 42.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4.05 gm (0.03 mole) of 4-propionylpyridine, 3.96 gm (0.03 mole) of t-butylcarbazate and 100 ml of absolute ethanol is refluxed 6 hr. The reaction mixture is treated with decolorizing carbon and filtered. The filtrate yields crystals on cooling. The product is collected, washed with Skellysolve B and dried to yield 3.16 gm (40%) of the title compound having a melting point of 170.1° C.

Workup

  1. additionThe reaction mixture is treated with decolorizing carbon
  2. filtrationfiltered
  3. customThe filtrate yields crystals
  4. temperatureon cooling
  5. customThe product is collected
  6. washwashed with Skellysolve B
  7. customdried

Sources & evidence

ORD record
ord-a077c238b91d40f6bfbeb44752511dc6
Source dataset
uspto-grants-1991_04
Patent number
US05011932

Reaction notes

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