反应详情

A mixture of 2.97 gm (0.0245 mole) of 4-acetylpyridine, 5.0 gm (0.0245 mole) of 4-trifluoromethylbenzhydrazide and 100 ml of absolute ethanol is refluxed for 6 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point, cooled to room temperature and chilled. The crystals which separate are collected, washed with water and dried to yield 6.29 gm (84%) of the title compound having a melting point of 198.4° C.

1. temperatureis refluxed for 6 hr
2. filtrationThe hot solution is filtered
3. additionThe filtrate is diluted with water to the cloud point
4. temperaturechilled
5. customThe crystals which separate
6. customare collected
7. washwashed with water
8. customdried