Acetohydrazide → HCID 3548684, compound

HRID 1085958Notes

Reaction equation

HRID 1085958 reaction equation
[C:1]([NH:4][NH2:5])(=[O:3])[CH3:2].[C:6]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)(=O)[CH3:7]>C(O)C>[N:12]1[CH:13]=[CH:14][C:9]([C:6](=[N:5][NH:4][C:1](=[O:3])[CH3:2])[CH3:7])=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 142824-Acetylpyridine

Product 1

HCID 3548684HCID 3548684, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.22 gm (0.03 mole) of acetic acid hydrazide, 3.63 gm (0.03 mole) of 4-acetylpyridine and 100 ml of absolute ethanol is refluxed 2 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point. The mixture is cooled to room temperature and then chilled in the refrigerator. The product is collected, washed with water and dried to yield 3.63 gm (69%) of the title compound having a melting point of 178.1° C.

Workup

  1. temperatureis refluxed 2 hr
  2. filtrationThe hot solution is filtered
  3. additionThe filtrate is diluted with water to the cloud point
  4. temperaturechilled in the refrigerator
  5. customThe product is collected
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-3d450c607ab646879cf3c0b92d302bba
Source dataset
uspto-grants-1991_04
Patent number
US05011932

Reaction notes

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