Cyclopropylamine → HCID 178500747, compound

HRID 1085984Notes

Reaction equation

HRID 1085984 reaction equation
[NH2:1][CH:2]=[C:3]([C:8](=[O:18])[C:9]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=1[Cl:17])[C:4]([O:6][CH3:7])=[O:5].[CH:19]1(N)[CH2:21][CH2:20]1>C(#N)C>[CH:19]1([NH:1][CH:2]=[C:3]([C:8](=[O:18])[C:9]2[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=2[Cl:17])[C:4]([O:6][CH3:7])=[O:5])[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 178500829HCID 178500829, compound

Product 1

HCID 178500747HCID 178500747, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2 g of the product from Example 5 and 0.62 g of cyclopropylamine were stirred in 30 ml of dry acetonitrile at room temperature for 30 minutes. The volatile constituents were then stripped off on a rotary evaporator and the evaporation residue was recrystallized from ether.

Workup

  1. customThe volatile constituents were then stripped off on a rotary evaporator
  2. customthe evaporation residue was recrystallized from ether

Sources & evidence

ORD record
ord-62d0e79a21074a8e908082a09579735a
Source dataset
uspto-grants-1991_04
Patent number
US05011971

Reaction notes

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