HCID 19748502, compound → 2-(1-AMINOETHYL)PHENOL HYDROCHLORIDE

HRID 1085996Notes

Reaction equation

HRID 1085996 reaction equation
[ClH:1].C([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17])C1C=CC=CC=1>[Pd].CO>[ClH:1].[OH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17]

Participants

4

Reactant 1

HCID 19748502HCID 19748502, compound

Product 1

HCID 197485242-(1-AMINOETHYL)PHENOL HYDROCHLORIDEYield 102.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture obtained by adding 2.64 g of (+)-1-(2-benzyloxyphenyl)ethylamine hydrochloride prepared in Referential Example (3-1) and 0.26 g of 5% Pd-C to 40 ml of methanol was subjected to hydrogenation at room temperature and normal pressure, whereby 256 ml of hydrogen was absorbed. After filtering off the catalyst, the filtrate was concentrated under reduced pressure to give 1.78 g of (+)-1-(2-hydroxyphenyl)ethylamine hydrochloride.

Workup

  1. customA mixture obtained
  2. customwas subjected to hydrogenation at room temperature
  3. customnormal pressure, whereby 256 ml of hydrogen was absorbed
  4. filtrationAfter filtering off the catalyst
  5. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b9077f68f29f493587d36c3c3cacab2c
Source dataset
uspto-grants-1991_04
Patent number
US05011989

Reaction notes

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