HuagongsheHuagongshe Chemistry Print Report · For research reference only
Metoclopramide sulfide → 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Metoclopramide sulfide | HCID 124098 | — |
| Reactant | 4-Amino-5-chloro-N-[2-(diethylamino]ethyl]-2-[4-(methylthio)butoxy]benzamide | HCID 14372577 | — |
| Product | 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[4-(methylsulfinyl)butoxy]benzamide | HCID 14372578 | 78% |
Reaction Steps
The general procedure from Example 21 is repeated except that the 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[2-(methylthio)ethoxy]benzamide utilized therein was replaced with the product from Step A to give the title compound in 78% yield after chromatography on silica and crystallization from methylene chloride-ether, as a solid, mp. 80°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05011992 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-3736ffac7be74bff8be8bf8d8d0b9c07 |
| Source note | uspto-grants-1991_04 |