HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetone → HCID 86742916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-hydroxybenzamide | HCID 15670820 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86742916 | HCID 86742916 | — |
Reaction Steps
When the starting benzamide intermediate from Example 74 is first reacted with one equivalent of sodium hydride in DMF and then to this is added on equivalent of chloroacetone and the mixture stirred for 5 h followed by heating to 50° for 30 min and workup, the title compound is isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05011992 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-f62dcd4776a446a8b6ce77750a9ef5aa |
| Source note | uspto-grants-1991_04 |