p-Toluenesulfonic acid → Ethyl 2-[bis(4-fluorophenyl)methylidene]-3-methylbutanoate

Participants

Reaction Steps

A mixture of ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)propionate (0.35 g, 1 mmol) and p-toluene sulfonic acid (0.1 g) in 20 mL toluene was heated at reflux for 1.5 hours. The mixture was concentrated in vacuo and the residue dissolved in diethyl ether. The ether solution was washed with saturated sodium bicarbonate solution, dried with magnesium sulfate and concentrated in vacuo. The residue was crystallized from cold petroleum ether to give 0.15 g of the title compound; m.p. =51.5°-52.5° C.

Provenance & Evidence