p-Toluenesulfonic acid → HCID 14371389, compound

Participants

Reaction Steps

A mixture of ethyl 2-cyclohexyl-3,3-bis(4-fluorophenyl)-3-hydroxypropionate (15.0 g, 38.6 mmol) and p-toluenesulfonic acid (2.5 g) in 250 mL of toluene was heated at reflux for 2 hours. The mixture was cooled, washed with water and saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated in vacuo. The residue was crystallized from hexane to give 13.3 g of the title compound; m.p. =50°-55° C.

Provenance & Evidence