p-Toluenesulfonic acid → HCID 15133041, compound

Participants

Reaction Steps

A solution of ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-methylpropionate (0.5 g, 1.6 mmol) and p-toluenesulfonic acid (0.18 g) in toluene was heated at reflux for 2.5 hours. The solution was cooled and washed with saturated sodium bicarbonate solution and water. The organic layer was dried with magnesium sulfate and concentrated in vacuo. The residue was purified by chromatography on silica eluting with 0.5% ethyl acetate in hexane to give 0.2 g of the product as a clear oil which was crystallized from petroleum ether to give 0.15 g of the title compound; m.p. =75°-76° C.

Provenance & Evidence