4,4'-Difluorobenzophenone → HCID 15133039, compound

Participants

Reaction Conditions

Reaction Steps

Lithium diisopropylamide (21.7 mL of 1.8M solution, 40 mmol) was added to a solution of ethyl 3,3-dimethylbutyrate (5.76 g, 40 mmol) in 40 mL of tetrahydrofuran at -35° C. After stirring for 30 minutes and further cooling to -50° C., 4,4'-difluorobenzophenone (4.36 g, 2 mmol) was added. The reaction was stirred for 2 hours at -50° and for 2 hours at -20° C. The mixture was quenched with 2N hydrochloric acid and extracted with diethyl ether. The extracts were dried and concentrated in vacuo. The residue was crystallized from petroleum ether to give 4.55 g of the title compound; m.p. =93°-96° C.

Provenance & Evidence