p-Toluenesulfonic acid → HCID 15133043, compound

Participants

Reaction Steps

A mixture of ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1,1-dimethylethyl)propionate (1.0 g, 2.8 mmol) and p-toluenesulfonic acid (0.3 g) in 20 mL toluene was heated at reflux for 45 minutes. The mixture was cooled and concentrated in vacuo. The residue was purified by chromatography on silica eluting with 1% ethyl acetate in hexane. Concentration of the appropriate fractions gave an oil which was crystallized from petroleum ether to give 0.35 g of the title compound; m.p. =60°-62° C.

Provenance & Evidence