Hydrochloric Acid → HCID 15133050, compound

Participants

Reaction Steps

Diisobutylaluminum hydride (6.6 mL of 1M solution, 6.6 mmol) was added to a solution of butyl 2-cyclohexyl-3,3-bis(4-fluorophenyl)propenoate (0.8 g, 2.2 mmol) in 10 mL of methylene chloride at -70° C. After stirring for 2.0 hours the mixture was hydrolyzed by adding 2N hydrochloric acid. The organic layer was separated, washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was crystallized from hexane to give 0.4 g of the title compound; m.p. =88°-90° C.

Provenance & Evidence