HCID 15133050, compound → HCID 15133056, compound

Participants

Reaction Steps

A solution of 2-cyclopropyl-3,3-bis(4-fluorophenyl)-2-propenol (0.3 g, 1.0 mmol) and pyridinium chlorochromate (0.5 g) in 20 mL of methylene chloride was stirred at 25° C for 18 hours during which time a gummy solid formed. The methylene chloride was decanted from the solid and the solution concentrated in vacuo. The residue was stirred with diethyl ether; the diethyl ether was decanted from some insoluble tar and the diethyl ether concentrated in vacuo. The residue was crystallized from petroleum ether to give 0.1 g of the title compound; m.p. =86°-88° C.

Provenance & Evidence