HCID 178455918, compound → HCID 178476302, compound

HRID 1086112Notes

Reaction equation

HRID 1086112 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:19]([NH:21][C@H:22]([C:30]([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[C@H:34]([CH2:36][CH3:37])[CH3:35])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28])=[O:20])[CH2:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]>C(O)(=O)C>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:19]([NH:21][C@H:22]([C:30]([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[C@H:34]([CH2:36][CH3:37])[CH3:35])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:28])[NH2:29])=[O:20])[CH2:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].[CH3:11][C:12]([OH:18])=[O:13]

Participants

3

Reactant 1

HCID 178455918HCID 178455918, compound

Product 1

HCID 178476302HCID 178476302, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

10.7 g of Z-Ile-Asp(OtBu)-Arg-Ile-OH are catalytically hydrogenated in 150 ml of 90% acetic acid in analogy to Example 1b.

Sources & evidence

ORD record
ord-762e8ee6b20b43aaba263de57584e89b
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

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