HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1086117Generated: November 2, 2026
Ethylmorpholine → Z-Pro-Val-Lys(Boc)-Val-OtBu
https://huagongshe.com/reaction/1086117
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-hydroxy-1,2,3-benzotriazin-4(3H)-one | HCID 73026 | — |
| Reactant | Z-Pro-val-OH | HCID 73512 | — |
| Reactant | HCID 131716852 | HCID 131716852 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Pro-Val-Lys(Boc)-Val-OtBu | HCID 131716851 | — |
Reaction Steps
0.38 ml of N-ethylmorpholine and 0.66 g of DCC are added, at 0° C., to a solution of 1.05 g of Z-Pro-Val-OH, 1.3 g of H-Lys(Boc)-Val-OtBu.HCl and 0.5 g of HOObt in 5 ml of dimethylformamide. The mixture is stirred at 0° C. for one hour and left to stand at room temperature overnight. The working-up is as in Example 8a. The residue is triturated with ether. The precipitate is filtered off with suction and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05011825 |
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| Source dataset | uspto-grants-1991_04 |
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| ORD ID | ord-facb688903db459ab7907fab4e460d5b |
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| Source note | uspto-grants-1991_04 |
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