L-Leucine → HCID 178476512, compound

HRID 1086120Notes

Reaction equation

HRID 1086120 reaction equation
[NH2:1][C@@H:2]([C:10]([NH:12][C@@H:13]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][C@H:29]([C:37]([NH:39][C@H:40]([C:45]([OH:47])=[O:46])[C@H:41]([CH2:43][CH3:44])[CH3:42])=[O:38])[CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:36])[NH2:35])=[O:27])[CH2:22][CH:23]([CH3:25])[CH3:24])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].N[C@@H:49]([C:54]([OH:56])=[O:55])[C@H](CC)C.N[C@H:58]([C:63]([OH:65])=[O:64])[C@H](CC)C.N[C@H](C(O)=O)CC(C)C.N[C@H](C(O)=O)CCCNC(=N)N>>[NH2:1][C@@H:2]([C:10]([NH:12][C@@H:13]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][C@H:29]([C:37]([NH:39][C@H:40]([C:45]([OH:47])=[O:46])[C@H:41]([CH2:43][CH3:44])[CH3:42])=[O:38])[CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:35])[NH2:36])=[O:27])[CH2:22][CH:23]([CH3:24])[CH3:25])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9].[CH3:49][C:54]([OH:56])=[O:55].[CH3:58][C:63]([OH:65])=[O:64]

Participants

6

Reactant 5

HCID 6106L-LeucineHCID 6306L-IsoleucineHCID 94206D-AlloisoleucineHCID 178418600HCID 178418600, compoundHCID 178455916HCID 178455916, compound

Product 1

HCID 178476512HCID 178476512, compound

Procedure

On purification of H-D-Arg-Ile-D-Leu-Arg-Ile-OH by column chromatography there was isolated a fraction which, according to amino acid analysis, was H-D-Arg-D-allo-Ile-D-Leu-Arg-Ile-OH. Amorphous substance, amino acid analysis: D-allo-Ile (0.9), Ile (1.06), Leu (1.03), Arg (1.87).

Workup

  1. customOn purification of H-D-Arg-Ile-D-Leu-Arg-Ile-OH by column chromatography
  2. customthere was isolated a fraction which

Sources & evidence

ORD record
ord-bd5785e0e0c5425c8ace4037e131a75e
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

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