HCID 178476536, compound → HCID 178476511, compound

Participants

Reaction Steps

670 mg of H-Arg-Val-Tyr(tBu)-Arg-Pro-OtBu triacetate are dissolved in a mixture of 10 ml of 90% trifluoroacetic acid and 1 ml of ethyl mercaptan. The solution is left to stand at room temperature for one hour, and is concentrated in vacuo. The residue is partitioned between water and tert.butyl methyl ether. The aqueous phase is stirred with a weakly basic ion exchanger (acetate form) until the pH has become 3.5-4.0. The ion exchanger is filtered off with suction, and the filtrate is freeze-dried.

Provenance & Evidence